Dissociation Between Thyroid Injury and Formation of Long-Acting Thyroid Stimulator in Thyrotoxicosis

Article1 August 1967Dissociation Between Thyroid Injury and Formation of Long-Acting Thyroid Stimulator in ThyrotoxicosisGERALD BURKE, M.D., C.M.GERALD BURKE, M.D., C.M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-349 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe long-acting thyroid stimulator (LATS) was first detected by Adams and Purves (1) who observed that the intravenous injection of serum from a patient with thyrotoxicosis caused a prolonged discharge of 131I from the thyroid glands of suitably prepared guinea pigs. The sustained time course of action of LATS was quite distinct from the relatively prompt and short-lived effects of pituitary thyrotropin and was the basis of the later, and now more widely used, bioassay procedure of McKenzie (2).Recent observations that LATS is an immunoglobulin G (3-6) have led to the hypothesis that LATS is an antibody formed in...References1. ADAMSPURVES DDHD: Abnormal responses in the assay of thyrotropin. Proc. Univ. Otago Med. Sch. 34: 11, 1956. Google Scholar2. MCKENZIE JM: The bioassay of thyrotropin in serum. Endocrinology 63: 372, 1958. CrossrefMedlineGoogle Scholar3. DORRINGTONMUNROCARNEIRO KJDSL: Reduction of gamma globulin with long-acting thyroid stimulating activity. Lancet 2: 889, 1964. CrossrefMedlineGoogle Scholar4. KRISSPLESHAKOVCHIEN JPVJR: Isolation and identification of long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema. J. Clin. Endocr. 24: 1005, 1964. CrossrefMedlineGoogle Scholar5. 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BURKE G: Failure of immunologic reaction of long acting thyroid stimulator (LATS) to thyroid components and demonstration of a plasma inhibitor of LATS. J. Lab. Clin. Med. 69: 713, 1967. MedlineGoogle Scholar10. BOYDEN SV: Adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J. Exp. Med. 93: 107, 1951. CrossrefMedlineGoogle Scholar11. BURKEFELDMAN GJM: Addison's disease and hyperthyroidism. Report of a case and demonstration of circulating adrenal and thyroid antibodies. Amer. J. Med. 38: 470, 1965. CrossrefMedlineGoogle Scholar12. WERNER SC: Hyperthyroidism: ocular manifestations, in The Thyroid, edited by WERNER, S. C. Hoeber Medical Division, Harper & Row, Inc., New York, 1962, p. 536. Google Scholar13. KRISSPLESHAKOVROSENBLUMHOLDERNESS JPVAM: Relation of circulating long-acting thyroid stimulator globulin (LATS) to the ophthalmopathy of Graves' disease: role of radioiodine treatment (abstract). Clin. 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BLAGG CR: Antibodies to thyroglobulin in patients with thyrotoxicosis treated with radioactive iodine. Lancet 2: 1364, 1960. CrossrefGoogle Scholar21. IRVINEMACGREGORSTUART WJAGAE: The prognostic significance of thyroid antibodies in the management of thyrotoxicosis. Lancet 2: 843, 1962. CrossrefMedlineGoogle Scholar22. HALESMYHILLRUNDLEMACKAYPERRY IBJFFIRB: Relation of eye signs in Graves' disease to circulating antibodies to thyroglobulin. Lancet 1: 468, 1961. CrossrefMedlineGoogle Scholar23. ANDERSONGRAYMIDDLETONYOUNG JRKGDGJA: Autoimmunity and thyrotoxicosis. Brit. Med. J. 2: 1630, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisFrom the Radioisotope Laboratory, Division of Metabolism and Endocrinology, Department of Medicine, Michael Reese Hospital and Medical Center, Chicago, Ill.This study was supported in part by general research support grant FR 5476-04, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Gerald Burke, M.D., Radioisotope Laboratory, Michael Reese Hospital, Chicago, Ill. 60616. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGraves’ Disease with Ophthalmopathy Following Radiotherapy for Hodgkin’s DiseaseEFFECT OF RADIOIODINE ON STIMULATORY ACTIVITY OF GRAVES’IMMUNOGLOBULINSLONG-ACTING THYROID STIMULATOR (LATS) AND LONG ACTING THYROID STIMULATOR PROTECTOR (LATS-P) IN UNTREATED THYROTOXICOSISEFFECTS OF RADIOIODINE ON THYROTROPHIN BINDING INHIBITING IMMUNOGLOBULINS IN GRAVES’DISEASEPretibial Myxoedema: A Clinical and Pathological StudyHypothyroid Graves' diseaseThe Long-Acting Thyroid Stimulator and the Result of I131Treatment for ThyrotoxicosisLymphocytic Thyroiditis and ThyrotoxicosisDer Long-Acting Thyroid Stimulator (LATS)Mechanisms of Graves' Disease and Endocrine ExophthalmosLong-Acting Thyroid Stimulator and ExophthalmosGERALD BURKE, M.D., C.M., F.A.C.PThe effect of radioablation of the thyroid gland in Graves' disease with high levels of long-acting thyroid stimulator (LATS)The long-acting thyroid stimulator of Graves' diseaseBeziehungen zwischen Exophthalmus-produzierendem Faktor (EPF), Thyreoidea-stimulierendem Hormon (TSH), „Long acting Thyroid stimulator“ (LATS) und zirkulierenden Antikörpern gegen Thyreoglobulin bei endemischem euthyreoten Jodmangelkropf 1 August 1967Volume 67, Issue 2Page: 349-355KeywordsBioassays and physiological analysisEndocrinologyGuinea pigsHospital medicineIntravenous injectionsMedical servicesResearch grantsResearch laboratoriesThyroidThyroid-stimulating hormone Issue Published: 1 August 1967 PDF DownloadLoading ...