Key result
Severe trauma linked to nonbacterial thrombotic endocarditis and fatal cerebroembolism, affecting ~21% of DIC patients.
Why the study?
Nonbacterial thrombotic endocarditis (NBTE) is a rare cause of fatal cerebroembolism that has been rarely reported after trauma, with limited awareness among clinicians.
Case Report (n=1)
Highlights the rare occurrence of nonbacterial thrombotic endocarditis in trauma patients and suggests surveillance echocardiography for high-risk critically ill patients.
May warrant vigilance for NBTE in trauma with DIC; leaves open whether screening or therapy improves outcomes.
Nonbacterial thrombotic endocarditis (NBTE) is a rare condition that may result in an unexpected and usually fatal cerebroembolism. It occurs in a variety of clinical situations, including malignancy, immune disorders, and sepsis, but it has rarely been reported after trauma. The formation of NBTE appears to require a hypercoagulable state and changes in valvular morphology, e.g., during a hyperdynamic state. Patients with disseminated intravascular coagulation have a 21% incidence of NBTE. Although NBTE is usually found at autopsy, premorbid detection by echocardiography is currently possible and feasible. Untreated patients have a high incidence of embolic events, but anticoagulation with heparin may be life-saving. A lethal case of NBTE in a severely injured patient is reported here with the purpose of increasing awareness among medical personnel caring for trauma patients. Recommendations have been made for surveillance echocardiography in high-risk patients, e.g., critically ill patients with sepsis or disseminated intravascular coagulation.
No takes yet. Share an insight, caveat, or question.
Sharma et al. (2000) conducted a case report in Nonbacterial thrombotic endocarditis (NBTE) in a trauma patient (n=1). Severe trauma was evaluated on Fatal cerebroembolism. Severe trauma can precipitate nonbacterial thrombotic endocarditis and fatal cerebroembolism, a condition that has a 21% incidence in patients with disseminated intravascular coagulation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: