Predictors and impact on disability of delirium in Covid-19: an observational study on 2288 consecutive hospitalized patients

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Backgrounds Delirium is a common event among Covid-19 hospitalized patients. In this work, we aim at evaluate the predictors of delirium and its impact on mortality and disability in Covid-19 patients. Methods Two thousand two hundred eighty-eight Covid-19 patients were admitted to Brescia hospital from 2020 to 2022. Clinical and laboratory features were extracted from digital medical records. Statistical analysis was implemented to evaluate predictive factors of delirium, mortality and disability at discharge. Results Out of 2288 patients, 223 (9.7%) experienced delirium (Del+). Compared to patients without delirium (Del-), Del+ subjects were older, exhibited worse premorbid conditions and disease severity, higher mortality rates and discharge outcomes. Age, premorbid disability and Covid-19 severity were the strongest predictors of both delirium and poor outcomes. Conclusion Older and frail Covid-19 patients are at higher risk of delirium, which is an important predictor of in hospital mortality and poor outcomes, independently from disease severity.