Key result
Spontaneous cardiac thrombosis affects ~40% of older APA hamsters, predominantly in the left atrium.
Why the study?
Spontaneous cardiac and renal lesions in APA hamsters were examined to characterize age-related non-neoplastic changes and their associations.
Observational
Answers are grounded in this paper and cite their sources.
Does not alter clinical practice; leaves open the APA hamster as a spontaneous left atrial thrombosis model for future research.
Spontaneous cardiac and renal lesions in APA hamsters were examined histopathologically. Myocardial degeneration, valvular thickening, coronary arterial degeneration and increase in heart weight were common in old hamsters. These changes, which suggest cardiac failure, seem to be related to cardiac thrombosis which predominantly affected the left atrium and was found in over 40% of each sex over 16 months of age. Neither glomerular amyloidosis nor arteriolar nephrosclerosis was detected. In general the histopathology of renal lesions in APA hamsters resembled that of the condition known as glomerulonephrosis in rats. Renal lesions occurred more frequently and more severely and developed more rapidly in females than in males. There was no apparent correlation between cardiac thrombosis and renal disease.
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Doi et al. (1987) conducted an observational in Spontaneous cardiac and renal lesions. Aging was evaluated on Cardiac thrombosis. Spontaneous cardiac thrombosis predominantly affected the left atrium in over 40% of APA hamsters over 16 months of age, with renal lesions occurring more frequently and severely in females.
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