Key result
AMI with obesity is linked to ~138% higher FABP4 and impaired carbohydrate metabolism versus controls.
Observational (n=209)
Yes
In patients with acute myocardial infarction, markers of energy homeostasis and adipokines are significantly altered and correlate with carbohydrate metabolism, with variations depending on the presence of obesity.
Altered adipokine and energy markers in AMI correlate with carbohydrate metabolism; hypothesis-generating for prognostic utility, pending prospective validation.
There have been reports on the effect of energy homeostasis markers and adipokines (FABP 4 and CTRP 3) on the development and course of cardiovascular disease in patients with concomitant obesity. The role of energy homeostasis and adipokines in the development of acute myocardial infarction and concomitant diseases is still insufficiently studied. The purpose of this work was to study the relationship between markers of energy homeostasis, adipokines and carbohydrate metabolism in patients with acute myocardial infarction and syntropic pathology. The study included 189 patients with acute myocardial infarction with and without obesity. The control group included 20 healthy individuals. Adropin, irisin, FABP 4, CTRP 3, insulin were determined by enzyme-linked immunosorbent assay. Mathematical computer processing of the findings obtained were performed using the software package "IBM SPPS Statistics 27.0" and Microsoft Office Excel. All groups of the patients were found to have increased levels of glucose, insulin, HOMA index compared with the control group (p˂0.05). The patients of all group demonstrated a decrease in adropine, irisin and CTRP 3 and an increase in FABP 4 when compared with the control group (p˂0.05). Analysis of the results points out the correlation between carbohydrate metabolism and the level of adropine, irisin, FABP 4, and CTRP 3 in all groups of the patients. Thus, the study has shown the influence of energy metabolism and adipokine system on carbohydrate metabolism in the patients with acute myocardial infarction depending on the presence and absence of obesity.
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M. Yu. Koteliukh (2020) conducted an observational in Acute myocardial infarction with and without obesity (n=209). Acute myocardial infarction with obesity vs. Healthy controls was evaluated on Serum FABP 4 level on days 1-2 (ng/ml) (p=<0.001). Acute myocardial infarction with concomitant obesity was associated with a significant increase in FABP 4 levels (11.97 vs 5.02 ng/ml) and a decrease in adropin, irisin, and CTRP 3 compared to healthy controls, correlating with impaired carbohydrate metabolism.
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