Key result
Vitamin D3 reduces prehypertensive arteriolar wall stress and distensibility in a PCOS rat model.
Why the study?
The effects of dihydrotestosterone-induced PCOS on arteriolar biomechanics and the modulatory role of vitamin D3 were unclear.
Does vitamin D3 improve arteriolar biomechanics in a dihydrotestosterone-induced rat model of polycystic ovary syndrome?
Does vitamin D3 improve arteriolar biomechanics in a dihydrotestosterone-induced rat model of polycystic ovary syndrome?
p-value: p=<0.05
In a rat model of PCOS, concomitant vitamin D3 administration reverses prehypertensive arteriolar biomechanical alterations caused by chronic DHT treatment.
Should not yet alter PCOS management; hypothesis-generating for vitamin D3 effects on arteriolar biomechanics in rat models.
UNLABELLED: To clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on arteriolar biomechanics in a rat model and the possible modulatory role of vitamin D3. METHODS AND RESULTS: The PCOS model was induced in female Wistar rats by ten-weeks DHT treatment. Arteriolar biomechanics was tested in arterioles by pressure arteriography in control as well as DHT- and DHT with vitamin D3-treated animals in contracted and passive conditions. Increased wall stress and distensibility as well as increased vascular lumen were detected after DHT treatment. Concomitant vitamin D3 treatment lowered the mechanical load of the arterioles and restored the vascular diameter. CONCLUSION: The hyperandrogenic state resulted in more rigid, less flexible arteriolar walls with increased vascular lumen compared with controls. DHT treatment caused eutrophic remodelling of gracilis arteriole. These prehypertensive alterations caused by chronic DHT treatment were mostly reversed by concomitant vitamin D3 administration.
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Sára et al. (2012) studied Polycystic ovary syndrome (PCOS) (n=30). Vitamin D3 vs. DHT alone and sham operation was evaluated on Tangential wall stress and distensibility of gracilis arterioles (p=<0.05). In a rat model of DHT-induced PCOS, concomitant vitamin D3 treatment reversed prehypertensive arteriolar biomechanical alterations, significantly reducing elevated tangential wall stress and distensibility (p<0.05).
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