Distinct Radiological and Clinical Appearance of Lymphocytic Hypophysitis

Lymphocytic hypophysitis is a rare inflammatory lesion of the pituitary gland. The disease shows a striking female predilection of approximately 9:1 and commonly affects young women during late pregnancy or in the postpartum period. Clinical presentation and radiological findings may mimic pituitary adenoma. We have reviewed the literature and report two cases of lymphocytic hypophysitis, neither of whom was neither pregnant or in the postpartum period; one of them (case 1) was a unique patient with empty sella associated with lymphocytic hypophysitis and diabetes insipidus established as a suprasellar mass.