Median facial cleft associated with ring E chromosome.

The purposes of this report are: (1) to describe the course of a newborn female with a ring E chro- mosome whose phenotype included microcephaly, median facial cleft, and hypotelorism, and (2) to re- view briefly reported ring E karyotypes. Case ReportThis term (gestation 42 weeks; weight 2508 g., length 43 cm.) female infant was born to a primiparous 19-year-old Caucasian mother and a 19-year-old Negro father.Pregnancy was complicated by maternal ex- posure to rubella during the third month of pregnancy, which was treated with 20 ml.y-globulin.Slight vaginal bleeding occurred during the 7th month of pregnancy and was treated with hydroxyprogesterone