Key result
In children hospitalized with rotavirus gastroenteritis, G4P[8] was the predominant genotype (60.2%), and specific genotypes like G1P[8] and G8P[8] significantly correlated with increased clinical severity such as vomiting and dehydration.
Why the study?
Rotaviruses are the leading cause of acute gastroenteritis in children, and the main circulating serotypes and their correlation with clinical symptoms before routine immunisation in Latvia were not well characterised.
What are the main circulating rotavirus genotypes and their correlation with clinical symptoms in children hospitalized with acute gastroenteritis in Latvia?
Cross-Sectional (n=527)
No
What are the main circulating rotavirus genotypes and their correlation with clinical symptoms in children hospitalized with acute gastroenteritis in Latvia?
p-value: p=<0.05
G4P[8] was the predominant rotavirus genotype in hospitalized children in Latvia before routine immunization, with specific genotypes correlating with clinical severity.
Genotype-symptom correlations in pre-vaccine Latvia support surveillance; leaves open whether associations persist post-vaccination or in other settings.
In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children’s Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.
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Laizāne et al. (2019) conducted a cross-sectional in Rotavirus gastroenteritis (n=527). Rotavirus genotypes vs. Other rotavirus genotypes was evaluated on Prevalence of rotavirus genotypes and their correlation with clinical manifestations (p=<0.05). In children hospitalized with rotavirus gastroenteritis, G4P[8] was the predominant genotype (60.2%), and specific genotypes like G1P[8] and G8P[8] significantly correlated with increased clinical severity such as vomiting and dehydration.
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