A general strategy for the synthesis of membrane-spanning bipolar phospholipids equipped with a reactive functional group probe of the membrane environment is described. The strategy is exemplified by the synthesis of a bisphosphatidylethanolamine that is connected through a benzylidene thioacetal of the ω-hydroxy esters at the sn-2 position of the two phosphoglycerol termini.
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Delfino et al. (1987) studied this question.
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