Modular Synthesis of 1,2‐Diamine Derivatives by Palladium‐Catalyzed Aerobic Oxidative Cyclization of Allylic Sulfamides
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Abstract
Allylic sulfamides undergo aerobic oxidative cyclization at room temperature, mediated by a Pd(O2CCF3)2/DMSO catalyst system in tetrahydrofuran. The cyclic sulfamide products are readily converted into 1,2-diamines, and substrates derived from chiral allylic amines cyclize with very high diastereoselectivity.
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Cite This Study
McDonald et al. (2010) studied this question.