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Periconiastone A ( 1 ), an ergosterol with an unprecedented pentacyclo[8.7.0.0 1,5 .0 2,14 .0 10,15 ]heptadecane system, was isolated from Periconia sp. TJ403-rc01. Its structure was assigned by extensive spectroscopic analyses and quantum-chemical 13 C NMR and ECD calculations. A vinylogous α-ketol rearrangement and an aldol condensation reaction during biosynthesis were proposed as key steps for the formation of 1 . Compound 1 showed antibacterial activity against Gram-positive S. aureus and E. faecalis with MIC values of 4 and 32 μg/mL, respectively.
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Gao et al. (2019) studied this question.
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