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The possible role of beta-endorphin (beta-EP) in mediating the analgesic effect elicited by electroacupuncture (EA) was assessed by injecting antiserum against beta-EP into the periaqueductal gray (PAG) of the rabbit. Two antisera (HO and UA) were raised in rabbits against human beta-EP, each of which recognized human, porcine, bovine, ovine, camel and rat beta-EP, the only difference being that HO recognized rabbit beta-EP while UA did not. The effect of EA analgesia was found to be seriously attenuated by injecting HO into PAG of the rabbit, while UA was ineffective. The results indicated a PAG pool of beta-EP as an important component in mediating EA analgesia.
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Xie et al. (1983) studied this question.
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