Key result
Low-volume high-intensity or combined exercise fails to change ANGPTL4 levels vs control in T2D.
Why the study?
The effect of personalized low volume-high intensity and combined strength-aerobic exercises on ANGPTL4 serum levels in women with type 2 diabetes was unclear.
Does personalized low volume-high intensity or combined exercise improve ANGPTL4 serum levels in overweight women with type 2 diabetes?
RCT (n=42)
Randomly divided
No
Does personalized low volume-high intensity or combined exercise improve ANGPTL4 serum levels in overweight women with type 2 diabetes?
An 8-week personalized exercise program did not significantly alter ANGPTL4 serum levels in overweight women with type 2 diabetes.
Short-term exercise does not modify ANGPTL4 in overweight women with T2D; challenges assumptions of rapid biomarker responsiveness and leaves duration effects open.
Background and Objectives: ANGPTL4 is a messenger protein that plays a role in regulating glucose and lipid metabolism.The aim of this study was to compare the effect of two personalized low volume-high intensity and combined (strength-aerobic) exercises on Angiopoietin-like protein 4 (ANGPTL4) protein serum levels in women with type 2 diabetes. Materials and Methods:In this clinical trial, 42 overweight diabetic women referred to Pars Clinic in Shahrekord were randomly divided into three groups of low-intensity exercise, combined strength-aerobic exercise, and control.They underwent training for 8 weeks.Data was analyzed using paired t-test and analysis of variance.Results: There was no significant difference between ANGPTL4 levels in pre-test and post-test (p>0.05).Conclusion: No significant change in ANGPTL4 serum levels following the two mentioned practices in women with type 2 diabetes was probably due to the short duration of the course, the age of the subjects and their level of fitness.
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Karami et al. (2020) conducted an RCT in Type 2 Diabetes (n=42). Low volume-high intensity exercise and combined strength-aerobic exercise vs. No regular exercise (Control) was evaluated on ANGPTL4 serum levels (p=0.982). Eight weeks of personalized low volume-high intensity or combined strength-aerobic exercise did not significantly change ANGPTL4 serum levels compared to control in overweight women with type 2 diabetes (p=0.982).
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