Aim: The serum trace elements statuses of sickle cell patients attending at General Hospital Owerri, Nigeria were investigated to determine whether or not the serum levels of these elements were normal. Materials and Methods: One hundred confirmed sickle cell patients (HbSS) age 5–30 years were selected. One hundred normal subjects (HbAA) age 5–30 years were used as control. Results: The levels of trace elements were significantly decreased in sickle cell anemia (p<0.05), except copper, when compared with the control. Conclusion: The result suggests, but not conclusively, that supplementation of sickle cell
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