“Double‐Click” Protocol for Synthesis of Heterobifunctional Multivalent Ligands: Toward a Focused Library of Specific Norovirus Inhibitors

Click, click, hooray! A convenient “double-click” protocol for the conjugation of two different ligands to multivalent scaffolds was developed. The protocol involves activation of the second attachment site as an azide for the second click reaction (see scheme). This method was used to synthesize potent inhibitors for norovirus-like particles.