Smaller Volume, Thickened Formulas in the Management of Gastroesophageal Reflux in Thriving Infants

BACKGROUND: The effect of smaller volume, thickened formulas on gastroesophageal reflux is not clear. METHODS: The frequency of gastroesophageal reflux and duration of acid pH in the esophagus were determined in six thriving infants using extended esophageal pH monitoring. RESULTS: There was a significant reduction in frequency of emesis and gastroesophageal reflux but not the duration of acid pH in the esophagus with the use of infant formula thickened with rice cereal to provide a nutritionally appropriate intake in a smaller volume. CONCLUSIONS: Thickening of formula with rice cereal in a nutritionally balanced form and smaller volume may be an appropriate strategy for reducing frequency of emesis and gastroesophageal reflux in thriving infants.