SUMMARY Two cases of mammary and one case of vulval Paget's disease are studied histologically and electronmicroscopically. There are no substantial morphological differences between those two types. The Paget cell has a characteristic fine structure: it lacks tonofibrils and shows many of the features of apocrine cells. Less highly differentiated keratinocytes lie adjacent to Paget cells and desmosomes exist between them. These observations suggest that Paget cells differentiate in situ from epidermal cells.
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Ruth E. Mitchell (1974) studied this question.
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