A light switch: A strategy for the photoregulation of hybridization by using the cis–trans photoisomerization of a photochromic nucleoside (PCN) is reported. This process enables the switch between duplexes and single strands in an extremely straightforward and reversible manner with light stimulation (see scheme), even at room temperature. Additionally, installation of PCNs into DNA had little influence on the B-form structure when the duplex was formed.
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Ogasawara et al. (2008) studied this question.
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