Key result
Achondroplasia disrupts normal endochondral ossification across all skeletal elements during intrauterine life.
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Historical definition of achondroplasia endures; leaves open its relevance to contemporary cardiovascular risk assessment.
Achondroplasia (micromelia, chondrodystrophia foetalis) has been defined as “an absence, arrest or perversion of the normal process of endochondral ossification of the most definite and universal character in every element of the skeleton, in which the process normally takes place during intrauterine life” (Symington and Thomson, 1892).
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Morris et al. (1953) studied this question. Achondroplasia is characterized by an absence, arrest, or perversion of normal endochondral ossification affecting every skeletal element during intrauterine life.
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