Bones from cortisone-treated and adrenalectomized mice were incubated in vitro and Ca and P in the medium measured after a steady state was reached. Compared to controls, no significant changes were seen in the adrenalectomized group. In the cortisone-treated group, while Ca concentrations were unchanged, P concentrations were depressed. It is therefore suggested that the depression of serum P levels with cortisone observed in rats and man may be in part a result of a change in distribution of P between bone mineral and extracellular fluid.
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Schartum et al. (1961) studied this question.