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January 1, 2008Chemical Communications

A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

Debabrata Chatterjee Anannya Mitra Aviva Levina Peter A. Lay

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Abstract

[RuIII(edta)(OH2/OH)]1-/2- (edta = ethylenediaminetetraacetate) inhibits protein tyrosine phosphatase (PTP) at physiological pH values in a mechanism that involves binding of the Cys residue of the catalytic domain of the enzyme and similar interactions may be important in the anti-cancer properties of the active forms of many Ru pro-drugs.

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Cite This Study

Chatterjee et al. (2008) studied this question.

synapsesocial.com/papers/6aae1224020104ad53f83dbc https://doi.org/10.1039/b803261k

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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