Without a trace…︁ The natural product epigallocatechin gallate (see scheme, right) and a library of derivatives were synthesized on a solid phase. Reductive etherification upon the release of the α-acyloxy ketone intermediate from the resin provided the desired epicatechin derivatives. Bn=benzyl, PS=polystyrene, TFA=trifluoroacetic acid.
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Tanaka et al. (2007) studied this question.
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