Antisynthetase syndrome positive for anti-threonyl-tRNA synthetase (anti-PL7) antibodies: Table 1–

B. Hervier; Y. Uzunhan; É. Hachulla; Olivier Benvéniste; Hilario Nunès; P. Delaval; L. Musset; Sylvain Dubucquoi; B Wallaert; M. Hamidou

doi:10.1183/09031936.00104310

February 28, 2011European Respiratory JournalOpen Access

Antisynthetase syndrome positive for anti-threonyl-tRNA synthetase (anti-PL7) antibodies: Table 1–

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Key Points

To delineate the clinical presentation and spectrum of organ involvement associated with anti-threonyl-tRNA synthetase (anti-PL7) autoantibodies in antisynthetase syndrome.
Assessed clinical, serological, and phenotypic records of individuals exhibiting anti-threonyl-tRNA synthetase (anti-PL7) antibodies.
Characterized patterns of systemic disease involvement, specifically tracking pulmonary, muscular, joint, and dermatologic presentations.
Anti-PL7 seropositivity correlates strongly with interstitial lung disease and myopathy, frequently marked by early or isolated pulmonary impairment.
Associated clinical features include arthritis, Raynaud phenomenon, and characteristic cutaneous signs such as mechanic's hands occurring alongside primary pulmonary-muscle manifestations.

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Implication

Clinical series demonstrates phenotypic manifestations in anti-PL7 antisynthetase syndrome, highlighting distinct patterns of pulmonary and muscle involvement.

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Hervier et al. (2011) studied this question.

synapsesocial.com/papers/6aae150aa4b849323664a336 https://doi.org/10.1183/09031936.00104310

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Antisynthetase syndrome positive for anti-threonyl-tRNA synthetase (anti-PL7) antibodies: Table 1–

Key Points

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Implication

Abstract

Discussion

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Antisynthetase syndrome positive for anti-threonyl-tRNA synthetase (anti-PL7) antibodies: Table 1–

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

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