Key result
Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are linked to adverse clinical outcomes and death.
Why the study?
Genome-wide association studies have identified gene variants associated with coronary artery disease risk, but their effect on disease progression is largely unknown.
Do genomic risk variants at 1p13.3, 1q41, and 3q22.3 predict subsequent cardiovascular outcomes in healthy individuals and those with established coronary artery disease?
Cohort (n=4,352)
Do genomic risk variants at 1p13.3, 1q41, and 3q22.3 predict subsequent cardiovascular outcomes in healthy individuals and those with established coronary artery disease?
Genomic risk variants at 1p13.3 and 1q41 are associated with subsequent clinical outcomes in patients with coronary artery disease, and 3q22.3 predicts cardiovascular risk in healthy individuals.
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These loci support hypothesis generation for outcome prediction; leaves open incremental value beyond clinical models pending validation.
Ellis et al. (2011) conducted a cohort in Healthy controls and established coronary artery disease (n=4,352). Genomic risk variants at 1p13.3 (rs599839), 1q41 (rs17465637), and 3q22.3 (rs9818870) vs. Non-carriers of the respective risk alleles was evaluated on Cardiovascular outcomes, anthropometric characteristics, neurohormonal analysis, and echocardiography. Genomic risk variants at 1p13.3 and 1q41 were associated with subsequent clinical outcomes in heart patients, and rs9818870 at 3q22.3 predicted death or admission in healthy individuals (P=0.045).
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