Key Messages•Selective intestinal epithelial permeability is essential for uptake of water and nutrients and contributes to oral tolerance development.•Altered intestinal epithelial barrier function and composition is observed in food allergy.•Subepithelial mediators and small intestinal luminal content influence barrier integrity.•The gastric milieu and physiological function contribute to antigen separation from the immune induction sites.•A dysfunctional barrier of the entire gastrointestinal tract has an essential contribution to food allergic reactions. •Selective intestinal epithelial permeability is essential for uptake of water and nutrients and contributes to oral tolerance development.•Altered intestinal epithelial barrier function and composition is observed in food allergy.•Subepithelial mediators and small intestinal luminal content influence barrier integrity.•The gastric milieu and physiological function contribute to antigen separation from the immune induction sites.•A dysfunctional barrier of the entire gastrointestinal tract has an essential contribution to food allergic reactions.
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Samadi et al. (2018) studied this question.
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