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The authors propose that collagen diseases and inflammatory bowel diseases represent immunosuppressive states, suggesting that clinicians should select immunopotentiation treatments rather than immunosuppression.
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The author proposes that collagen and inflammatory bowel diseases are characterized by an immunosuppressive state and should be treated with immunopotentiation rather than conventional immunosuppression.
Many clinicians have considered that collagen diseases (or autoimmune diseases) may be at activated immune states and have therefore used steroid hormones and other immunosuppressive drugs for the treatment.However, these diseases seem to be worsened by the treatment after all.The immunologic state similar to collagen diseases is also seen in aging, showing the appearance of autoreactive T cells and autoantibody-producing B cells.In fact, conventional lymphocytes rather decrease in patients with collagen diseases or autoimmune diseases and inversely granulocytes increase.In other words, these patients are at immunosuppressive states, showing the increase of granulocytes, extratltymic T cells, and autoantibody-producing B cells.Infections or stress may induce these immunologic states in the patients.Patients with inflammatory bowel diseases also show granulocytosis and lymphocytopenia but clinicians use NSAlDs and steroid hormones which have the activating potential of granulocytes.I propose here that clinicians should select the treatments of imrnunopotentiation rather than those of immunosuppression for these patients with collagen diseases or inflammatory bowel diseases.
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Abo et al. (2002) conducted a review in Collagen diseases and inflammatory bowel diseases. Immunopotentiation vs. Immunosuppression was evaluated. The authors propose that collagen diseases and inflammatory bowel diseases represent immunosuppressive states, suggesting that clinicians should select immunopotentiation treatments rather than immunosuppression.
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