Radionuclide with Cerenkov radiation (CR) can serve as an internal excitation source to activate photosensitizers for photodynamic therapy (PDT) in deep tumor. However, the low efficiency of CR limits its therapeutic efficacy. A 131I labeled zinc tetra(4‐carboxyphenoxy) phthalocyaninate (ZnPcC4) conjugated Cr3+‐doped zinc gallate (ZnGa2O4:Cr3+, ZGCs) nanoplatform (131I‐ZGCs‐ZnPcC4) is developed for radiotherapy (RT) and radiation‐induced PDT. 131I can not only activate ZGCs for long‐lasting luminescence via both Cerenkov luminescence (CL) and ionizing radiation, which further continuously activate photosensitizer ZnPcC4 for PDT, but also can directly kill cancerous cells. This 131I‐ZGCs‐ZnPcC4 exhibits excellent tumor inhibition both in vitro and in vivo. Combining self‐activated PDT and RT, it is believed that the 131I‐ZGCs‐ZnPcC4 can greatly benefit the deep tumor therapy.
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Wang et al. (2020) studied this question.