Key result
Adding C-protein to myosin yields thinner filaments and alters length based on dilution rate.
Why the study?
The effect of C-protein on the assembly reaction of myosin filaments and filament length modulation was not fully understood.
Population
In vitro myosin filaments
Comparison
Presence vs absence of C-protein and different dilution rates
Design
Experimental study using flow birefringence, electron microscopy, and ultracentrifugation
Authors
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Does not alter practice; leaves open C-protein's role in cardiac sarcomere assembly in vivo.
This basic science study demonstrates that C-protein modulates the assembly and dimensions of myosin filaments in vitro.
Miyahara et al. (1980) studied this question. C-protein was evaluated on Myosin filament assembly and elongation. Addition of C-protein to myosin during assembly resulted in thinner filaments and favored the formation of longer or shorter filaments depending on the dilution rate.
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