What question did this study set out to answer?

To determine whether mannan-binding lectin deficiency or related gene mutations increase the risk of hospitalization for respiratory syncytial virus lower respiratory tract infection in infants.

July 5, 2004Scandinavian Journal of ImmunologyOpen Access

Mannan‐Binding Lectin and RSV Lower Respiratory Tract Infection Leading to Hospitalization in Children: A Case–Control Study from Soweto, South Africa

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Authors

IKInes Ackerl KristensenAarhus University Hospital STSteffen ThielAarhus University RSR. SteffensenAalborg University Hospital

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Implication

Case-control study finds no link between mannan-binding lectin deficiency and RSV hospitalization in infants, suggesting this immune component does not influence severe respiratory disease risk.

Key Points

To determine whether mannan-binding lectin deficiency or related gene mutations increase the risk of hospitalization for respiratory syncytial virus lower respiratory tract infection in infants.
Conducted a case–control study matching 55 hospitalized infants with respiratory syncytial virus lower respiratory tract infection to 113 age- and sex-matched outpatient clinic controls.
Identified cases via surveillance at Chris Hani Baragwanath Hospital and controls from four regional immunization clinics, with 76% of all participants under 6 months of age.
Quantified circulating mannan-binding lectin levels and genotyped mutations in exon 1 and the gene promoter region.
Low serum concentrations of mannan-binding lectin did not associate with hospitalization for respiratory syncytial virus lower respiratory tract infection (OR 1.00, 95% CI 0.99–1.03).
Carriage of variant alleles in the mannan-binding lectin gene was not significantly associated with severe infection (OR 1.24, 95% CI 0.73–2.12).

Cite This Study

Kristensen et al. (2004) studied this question.

synapsesocial.com/papers/6aae2550c772adbcab5e5e6f https://doi.org/10.1111/j.0300-9475.2004.01466.x

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Implication

Case-control study finds no link between mannan-binding lectin deficiency and RSV hospitalization in infants, suggesting this immune component does not influence severe respiratory disease risk.

Mannan‐Binding Lectin and RSV Lower Respiratory Tract Infection Leading to Hospitalization in Children: A Case–Control Study from Soweto, South Africa

Discussion

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Implication

Key Points

Cite This Study

Mannan‐Binding Lectin and RSV Lower Respiratory Tract Infection Leading to Hospitalization in Children: A Case–Control Study from Soweto, South Africa

Discussion

Member takes

Implication

Key Points

Cite This Study

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