Biodegradable, biocompatible and nontoxic nonionic surfactants are widely used in food, pharmaceutical and industrial applications being commonly produced based on alkaline-catalyzed chemical glycerolysis of natural oil and fats at high temperatures and elevated pressure under nitrogen atmosphere. In this work we have optimized a biocatalytic continuous flow process with packed bed reactor for the esterification reaction between ( R, S )-1,2-isopropylidene glycerol and stearic acid using response surface methodology (RSM) leading to the desired product in excellent conversion (95%) and short reaction time (40 s of residence time).
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Itabaiana et al. (2011) studied this question.
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