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In this work, a peptide [2]catenane was created by exploiting the strong tendency of the Pro-Gly-Pro (PGP) sequence to fold into an Ω-loop. Ditopic heptapeptide ligand 1, which includes the PGP sequence, formed peptide [2]catenane 2 on complexation with Ag+. Moreover, addition/removal of Na+ triggered a reversible structural change between 2 and twisted macrocycle 3.
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Sawada et al. (2017) studied this question.
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