Key result
Antithrombotic therapy is not associated with higher postoperative complications after propensity matching.
Why the study?
The safety of gastrectomy for patients receiving antithrombotic agents remains unclear despite many studies on perioperative management of antithrombotic therapy.
Does antithrombotic therapy increase postoperative complication rates in patients undergoing gastrectomy for primary gastric adenocarcinoma?
Cohort (n=548)
No
Does antithrombotic therapy increase postoperative complication rates in patients undergoing gastrectomy for primary gastric adenocarcinoma?
Patients receiving antithrombotic therapy can safely undergo gastric resection without a significantly increased risk of postoperative complications after adjusting for baseline differences.
No increased complications with antithrombotic therapy after matched gastrectomy; hypothesis-generating and requires randomized confirmation before practice change.
Background: With the aging population, more patients are expected to receive antithrombotic treatment. Although many studies have investigated the perioperative management of antithrombotic therapy, few have targeted gastrectomy. Hence, the safety of gastrectomy for patients receiving antithrombotic agents remains unclear. This retrospective cohort study sought to compare outcomes between patients who did and did not receive antithrombotic agents.Methods: This single-center retrospective cohort study included 548 patients who underwent gastrectomy for primary gastric adenocarcinoma from January 2011 to December 2019. Patients were subsequently classified into two groups according to whether they received antithrombotic therapy (n = 121) or not (n = 427), after which surgical outcomes were compared. Propensity score analysis was performed based on age, sex, body mass index, open versus laparoscopic surgery, and total versus distal gastrectomy. After propensity score matching, 121 patients were included in each group.Results: Among the entire cohort, receiving antithrombotic therapy group was significantly older than those who did not (age ≥ 75 years, 48% vs. 33%; p ≤ 0.0001). Those receiving antithrombotic therapy had significantly higher postoperative complication rates than those who did not (33.1% vs. 23.9%; p = 0.046). After matching, no significant difference in the postoperative complication rate was observed between both groups.Conclusion: Despite having a high risk for postoperative complications, patients receiving antithrombotic therapy can safely undergo gastric resection.
No takes yet. Share an insight, caveat, or question.
Kudo et al. (2021) conducted a cohort in Primary gastric adenocarcinoma (n=548). Antithrombotic therapy vs. No antithrombotic therapy was evaluated on Postoperative complications (Clavien-Dindo ≥ II) (p=0.046). Patients receiving antithrombotic therapy had a higher crude rate of postoperative complications (33.1% vs 23.9%, p=0.046), but this difference was not significant after propensity score matching.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: