The central aim of standardization is to have accurate, reproducible apo A-I and B measurements for use in defining a person's risk for cardiovascular disease or in evaluating a therapeutic response. A common accuracy-based standardization program is indispensable in establishing international reference intervals for clinical use. It is therefore important that the standardization be implemented as soon as possible. Many problems of the standardization of apo A-I and B measurements have been presented and discussed in this meeting. Although immediate solutions to all the problems were not evident, following the recommendations from this meeting can significantly improve the standardization process. The next step is to determine uniform reference intervals, followed by a consensus conference on apolipoproteins to define the cutpoints (cutoff values) for clinical decisions.
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Marcovina et al. (1989) studied this question.