The matrix metalloproteinases (MMPs) are a family of endopeptidases that are involved in the degradation and remodelling of the extracellular matrix of connective tissues and basement membranes. There is increasing evidence that these molecules are involved in a variety of degradative diseases such as arthritis and cancer. This review summarises recent developments in the design and application of small molecule MMP inhibitors disclosed in the recent patent and primary literature.
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Porter et al. (1995) studied this question.
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