Collagen fibrils have been identified by electron microscopy and hydroxyproline assay in synovial fluid sediments from patients with a variety of joint diseases. Phase contrast and polarized light microscopy alone proved inadequate to distinguish these fibrils from fibrin strands. The potential sources and significance of the presence of collagen fibrils in synovial fluid sediments are discussed.
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Kitridou et al. (1969) studied this question.
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