Quinoline Derivatives: In Vitro Antimicrobial Study

Some quinoline derivatives were synthesized and their structures were confirmed by IR, 1H NMR and mass spectroscopy. Screening of all these synthesized compounds were done in vitro against four Gram positive bacteria, four Gram negative bacteria and four fungal strains in dimethyl sulphoxide and N, N-dimethyl formamide. It is observed that N, N-dimethyl formamide is good solvent for the these compounds in selected strains and compounds containing cyano and nitro groups are more effective in inhibiting these strains.