ro ve Maike ter Wolbeek, Lorenz J.P. van Doornen, Annemieke Kavelaars, c d a, in self-reported complaints between CFS patients and fatigued participants. Interestingly, CFS patients showed a distinct immune profile from an adolescent population recently demonstrated that fatigue was strongly related to pain, unrefreshing sleep and cognitive problems (Ter Wolbeek et al., 2006). In addition, resulting in high rates of school absenteeism (Ter Wolbeek et al., 2006). Findings in adults suggest that unexplained severe fatigue is a predictor for later development of chronic fatigue syndrome (CFS) (Wessely et al., 1995; Hui-bers et al., 2004). Therefore, followup studies concerning symptoms and underlying mechanisms of fatigue in
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Ader et al. (1987) studied this question.