Patent Review of Synthetic Routes and Crystalline Forms of the CFTR-Modulator Drugs Ivacaftor, Lumacaftor, Tezacaftor, and Elexacaftor

This review surveys synthetic routes and polymorphic forms of the three approved CFTR-modulators ivacaftor, lumacaftor, and tezacaftor and one Phase 3 development candidate, elexacaftor. The patent literature was the source of information for synthetic routes and final forms.