Key result
IV furosemide and diazepam associated with a ~19 mmHg SBP reduction in hypertensive emergencies.
Why the study?
Hypertensive crises with severe hypertension pose immediate life-threatening risks and require effective prehospital treatment strategies.
Does the addition of nifedipine to furosemide and diazepam improve blood pressure reduction in patients with hypertensive crisis in a prehospital setting?
Observational (n=160)
No
Does the addition of nifedipine to furosemide and diazepam improve blood pressure reduction in patients with hypertensive crisis in a prehospital setting?
The addition of nifedipine to furosemide and diazepam provides greater reduction in systolic and diastolic blood pressure for prehospital treatment of hypertensive emergencies.
Cohort findings on hypertensive crisis should not yet change practice; leaves open optimal management strategies pending prospective trials.
People with arterial blood pressure >140/90 mmHg (hypertension) have accelerated development of atherosclerosis and changes in blood vessels and other organs of the body, therefore, such arterial blood pressure must be treated. A hypertensive crisis is defined as an extreme increase in arterial blood pressure with a systolic blood pressure over 180 mmHg and diastolic blood pressure over 120 and 130 mmHg, respectively, and poses an immediate danger to the patient's life. At the heart of each hypertensive crisis is severe hypertension. In the Emergency medicine center Zivinice has been carried out a prospective study ehich include four study groups were formed as a sequential sample of 160 participants of both sexes. By administering a combination of furosemide amp. And diazepam amp. The mean systolic blood pressure in all observed groups decreased from 186.25 mmHg to 167.5 mmHg, and the mean diastolic blood pressure decreased from 120.53 mmHg to 97.5 mmHg. By prescribing a combination of nifedipine tab., furosemide amp. and diazepam amp., the average systolic blood pressure all observed groups was reduced from 186.25 mmHg to 152 mmH, and the average diastolic blood pressure was reduced from 120.53 mmHg to 91.2 mmHg.
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Jagodic et al. (2022) conducted an observational in Hypertensive crisis (n=160). Furosemide and diazepam vs. Baseline (pre-treatment) was evaluated on Mean systolic blood pressure (p=<0.001). Administration of intravenous furosemide and diazepam significantly reduced mean systolic blood pressure from 186.25 mmHg to 167.5 mmHg in patients presenting with hypertensive emergencies.
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