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BACKGROUND: The functional Ser326Cys polymorphism in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in gastric cancer risk. However, the published findings are inconsistent. We therefore carried out a meta-analysis to investigate this relationship. METHODS: Nine published case-control studies, including 1180 gastric cancer cases and 2444 controls, were identified. Odds ratios and 95% confidence intervals were used to assess the strength of the association. RESULTS: Overall, the hOGG1 Ser326Cys polymorphism was significantly associated with an increased risk of gastric cancer in a recessive model (Cys/Cys vs. Ser/Cys+Ser/Ser: odds ratio=1.31, 95% confidence interval: 1.03-1.67). In the stratified analysis, a significant association was also observed among Asian populations and hospital-based controls. However, when stratified by smoking status of gastric cancer patients, no statistically significant result was found. CONCLUSION: Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism may contribute to susceptibility to gastric cancer.
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Ni et al. (2012) studied this question.
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