December 3, 2015Journal of Hypertension

Adoptive transfer of Treg-deficient Scurfy T cells exaggerated Angiotensin II-induced microvascular injury, endothelial dysfunction, and oxidative stress compared to wild-type T cells.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Angiotensin II-induced microvascular injury. Intervention: Adoptive transfer of Scurfy T cells (Treg deficient) vs. Vehicle or wild-type T cells. Primary outcome: Microvascular injury, endothelial dysfunction, and oxidative stress.

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Why the study?

Does FOXP3+ Treg deficiency exaggerate Angiotensin II-induced microvascular injury in Rag1 knockout mice?

Population

T and B-cell-deficient recombination-activating gene 1 (Rag1) knockout mice

Comparison

Injection of 10^7 T cells from Scurfy mice… vs Injection with vehicle, 10^7 T cells from…

Design

Preclinical

Follow-up

14 days

Key result

Adoptive transfer of Treg-deficient Scurfy T cells exaggerated Angiotensin II-induced microvascular injury, endothelial dysfunction, and oxidative stress compared to wild-type T cells.

Authors

MMMuhammad Oneeb Rehman Mian TBTlili Barhoumi MBMarie Briet

Discussion

Member takes

Overview

Treg transfer may protect against Ang II vascular injury in mice; hypothesis-generating, should not yet change clinical practice.

Structured PICO

Does FOXP3+ Treg deficiency exaggerate Angiotensin II-induced microvascular injury in Rag1 knockout mice?

Population

Rag1 knockout mice infused with Angiotensin II to study the effects of T-regulatory cell deficiency on microvascular injury over 14 days.

Intervention

Injection of 10^7 T cells from Scurfy mice (Treg deficient) followed by Angiotensin II infusion (490 ng/kg per min, subcutaneous) for 14 days

Comparator

Injection with vehicle, 10^7 T cells from wild-type mice, or 10^6 wild-type Treg alone or in combination with Scurfy T cells, followed by Angiotensin II infusion

Outcome

Microvascular damage (endothelial dysfunction, oxidative stress, microvascular remodeling, and stiffness)surrogate

FOXP3+ T-regulatory cell deficiency exacerbates Angiotensin II-induced microvascular injury, highlighting the protective role of Tregs against vascular damage.

Cite This Study

Mian et al. (2015) studied Angiotensin II-induced microvascular injury. Adoptive transfer of Scurfy T cells (Treg deficient) vs. Vehicle or wild-type T cells was evaluated on Microvascular injury, endothelial dysfunction, and oxidative stress. Adoptive transfer of Treg-deficient Scurfy T cells exaggerated Angiotensin II-induced microvascular injury, endothelial dysfunction, and oxidative stress compared to wild-type T cells.

synapsesocial.com/papers/6aae477eb879726e555f35c5 https://doi.org/10.1097/hjh.0000000000000761

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December 3, 2015Journal of Hypertension

Adoptive transfer of Treg-deficient Scurfy T cells exaggerated Angiotensin II-induced microvascular injury, endothelial dysfunction, and oxidative stress compared to wild-type T cells.

View Full Paper

Ask AI

Bookmark

Why the study?

Does FOXP3+ Treg deficiency exaggerate Angiotensin II-induced microvascular injury in Rag1 knockout mice?

Population

T and B-cell-deficient recombination-activating gene 1 (Rag1) knockout mice

Comparison

Injection of 10^7 T cells from Scurfy mice… vs Injection with vehicle, 10^7 T cells from…

Design

Preclinical

Follow-up

14 days

Key result

Adoptive transfer of Treg-deficient Scurfy T cells exaggerated Angiotensin II-induced microvascular injury, endothelial dysfunction, and oxidative stress compared to wild-type T cells.

Authors

MMMuhammad Oneeb Rehman Mian TBTlili Barhoumi MBMarie Briet

Discussion

Member takes

Overview

Treg transfer may protect against Ang II vascular injury in mice; hypothesis-generating, should not yet change clinical practice.

Structured PICO

Does FOXP3+ Treg deficiency exaggerate Angiotensin II-induced microvascular injury in Rag1 knockout mice?

Population

Rag1 knockout mice infused with Angiotensin II to study the effects of T-regulatory cell deficiency on microvascular injury over 14 days.

Intervention

Injection of 10^7 T cells from Scurfy mice (Treg deficient) followed by Angiotensin II infusion (490 ng/kg per min, subcutaneous) for 14 days

Comparator

Injection with vehicle, 10^7 T cells from wild-type mice, or 10^6 wild-type Treg alone or in combination with Scurfy T cells, followed by Angiotensin II infusion

Outcome

Microvascular damage (endothelial dysfunction, oxidative stress, microvascular remodeling, and stiffness)surrogate

FOXP3+ T-regulatory cell deficiency exacerbates Angiotensin II-induced microvascular injury, highlighting the protective role of Tregs against vascular damage.

Cite This Study

synapsesocial.com/papers/6aae477eb879726e555f35c5 https://doi.org/10.1097/hjh.0000000000000761

Also Consider

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