Effect of refractive status and axial length on retinal nerve fiber layer thickness using OCT

Aim of workTo evaluate the effect of refractive status and axial length of the eye on retinal nerve fiber layer (RNFL) thickness.Method A total of 116 eyes of 62 subjects were enrolled in the study.RNFL thickness was measured using TOPCON 3D OCT 2000. ResultsHyperopic group, as compared to normal, did not show any significant thickening for average, superior, inferior, nasal, and temporal quadrants (p = 0.760 , p = 0.160, p = 0.139, p = 0.345, p = 0.762, respectively).Also myopic group, as compared to normal, did not show any significant thinning for average, superior, inferior, nasal, and temporal quadrant (p = 0.991, p = 0.746, p = 0.848 p = 0.382, p = 0.894, respectively).The RNFL thickness decreased with increasing axial length and this was statistically significant in average, superior, inferior, and nasal quadrants (p = 0.0009***, p = 0.0003***, p = 0.0031**, p = 0.0129**, respectively), except for temporal quadrant (p = 0.8118).conclusion Neither hyperopia nor myopia affect retinal nerve fiber layer thickness significantly.The RNFL thickness decreased with increasing axial length and this was statistically significant in average, superior, inferior, and nasal quadrants except for temporal quadrant