Key result
Nucleotides evoke ~90% relaxation of murine aortic rings via functional endothelial P2Y receptors.
Why the study?
The characterization of P2Y receptors on endothelial cells of the mouse aorta and their role in nucleotide-evoked vasodilatation was not fully understood.
Functional P2Y1, P2Y2, and P2Y6 receptors are present on murine aorta endothelial cells and mediate nucleotide-induced vasorelaxation.
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Does not inform clinical practice; extends rodent models of endothelial P2Y receptor function.
Guns et al. (2005) studied this question. Nucleotides (ATP, UTP, UDP, ADP) was evaluated on Relaxation of phenylephrine precontracted thoracic aortic rings. Nucleotides (ATP, UTP, UDP) evoked complete (>90%) relaxation of precontracted murine thoracic aortic rings, indicating functional P2Y1, P2Y2, and P2Y6 receptors on endothelial cells.
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