Enantioselective Total Synthesis of the Cyclophilin-Binding Immunosuppressive Agent Sanglifehrin A This work was financially supported by Eli Lilly and Company and a Robert Mayer Graduate Fellowship (to M.D.). We thank Prof. K. C. Nicolaou for providing authentic spectra of 1.

Crafting of the building blocks 1–3 allows the convergent conjoining of 2–3 in advance of macrolactonization. The subsequent linkup of the eastern sector with 1 by Stille coupling enabled the convenient stereocontrolled assembly of the immunosuppressive agent (−)-sanglifehrin A (Boc=tert-butoxycarbonyl).