Key result
First-order kinetics of angiotonin formation and destruction allow accurate measurement of renin and angiotonase activity.
Why the study?
The physicochemical basis and kinetic properties of the renal vasopressor system enzymes renin and angiotonase required clarification and standardization.
Population
Kidney extracts and alpha-globulin fraction of serum in vitro
Comparison
Kinetic analysis of renin and angiotonase enzyme activities
Design
Preclinical kinetic study of enzyme reactions
Authors
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Reaction constants should quantify renin-angiotensin enzyme activity; leaves open clinical translation pending further study.
This foundational biochemical study establishes the first-order kinetics of the renin-angiotonin system and provides a method for standardizing renin and angiotonase activity.
Plentl et al. (1943) studied this question. The formation and destruction of angiotonin follow first-order kinetics, allowing the reaction constants to accurately express the activity of the enzymes renin and angiotonase.
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