Proteins destined for degradation in the cell9s garbage disposal unit, the proteasome, must first receive a ubiquitin tag. In his Perspective, Hochstrasser discusses new work (Vermaet al., Copeet al.) that reveals the vital link between removal of the ubiquitin tag in the proteasome and degradation of the targeted protein. Proteins are deubiquitinated in the proteasome by a zinc-dependent metalloprotease, and protein degradation cannot take place in the absence of this enzyme.
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Mark Hochstrasser (2002) studied this question.
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