Answers are grounded in this paper and cite their sources.
Ferrocenyl carboxylic acid derivatives were metalated with TMPMgCl·LiCl, leading after reaction with electrophiles to 1,2-disubstituted ferrocenes. Further metalation of these disubstituted ferrocenes with TMPMgCl·LiCl afforded trisubstituted ferrocenes. A 1,2,3,4-tetrasubstituted ferrocene derivative could also be prepared in this way.
No takes yet. Share an insight, caveat, or question.
Stoll et al. (2007) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: