Cu(II), Ni(II) and Co(II) Complexes of Malonic Acid Dihydrazide with Bis-BrSalicylhydrazone

New complexes of Cu(II), Ni(II), and Co(II) with N1,N3-bis(5-bromo-2-hydroxybenzylidene)-malonohydrazide (LH4) have been synthesized. It was shown that, in the synthesized Cu(II) and Co(II) complexes with the LH4 ligand, coordination occurs according to the Schiff base type, while in the Ni(II) complex the oxygen atom of the amide (hydrazide) group in the enol form and the nitrogen atom of the azomethine group take part in the coordination groups. Based on the data of IR, electron spectroscopy, EPR, thermogravimetry and elemental analysis of the obtained complexes, the octahedral coordination of Cu(II) ions and the binuclear structure of the complexes are assumed. It was established that all obtained compounds have high bactericidal and fungicidal activity. After, the activities of the studied ligand and its metal complexes against various cancer proteins including breast, colon, and lung cancer were compared.