Key result
Triamcinolone at 35 weeks gestation disrupts circadian hormone rhythms and alters FHR patterns versus control.
Why the study?
The effects of fetal and maternal adrenal gland suppression on fetal heart rate patterns and behavior were not well understood.
Does fetal and maternal adrenal gland suppression with triamcinolone modify fetal heart rate patterns and maternal hormone rhythms in healthy pregnant women?
Comparison
Triamcinolone administration vs control group
Design
Double-blind study
Follow-up
3 weeks
Authors
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Corticosteroid exposure transiently alters fetal heart rate rhythms; extends evidence that adrenal suppression modifies fetal behaviour in late gestation.
RCT (n=10)
Double-blind
Does fetal and maternal adrenal gland suppression with triamcinolone modify fetal heart rate patterns and maternal hormone rhythms in healthy pregnant women?
Fetal and maternal adrenal gland suppression with triamcinolone transiently modifies fetal heart rate patterns and maternal hormone circadian rhythms.
Arduini et al. (1986) conducted an RCT in Healthy pregnancy (n=10). Triamcinolone vs. Control was evaluated on Fetal heart rate (FHR) patterns and maternal hormone circadian rhythms. Triamcinolone administration at 35 weeks of gestation caused a loss of circadian hormone rhythms and modified ultradian and circadian patterns of fetal heart rate compared to control.
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